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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Estimated data generated using the EPI Suite model developed by the USEPA.
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
HYDROWIN Program (v2.00) from EPI Suite estimation database
GLP compliance:
no
Radiolabelling:
no
Analytical monitoring:
no
Estimation method (if used):
HYDROWIN v2.00
Positive controls:
no
Negative controls:
no
Transformation products:
not specified
pH:
7
Temp.:
25 °C
DT50:
61.4 d
Type:
other: estimated data
Remarks on result:
other: other details not available
pH:
8
Temp.:
25 °C
DT50:
6.14 d
Type:
other: estimated data
Remarks on result:
other: other details not available
Hydrolysis rate constant:
1.31 s-1
Type:
other: estimated
Remarks on result:
other: other details not available
Validity criteria fulfilled:
not specified
Conclusions:
The half life of hydrolysis of test chemical was estimated to be 61.4 and 6.14 days at pH 7 and 8 respectively, the hydrolysis rate constant was estimated to be
1.31 L/mol-sec. On the basis of half life value test chemical is considered to be stable.

Executive summary:

The half life of test chemical was estimated by using the EPI suite Hydrowin model.

The half life of hydrolysis of test chemical was estimated to be 61.4 and 6.14 days at pH 7 and 8 respectively, the hydrolysis rate constant was estimated to be 1.31 L/mol-sec. On the basis of half life value test chemical is considered to be stable.

Description of key information

The half life of test chemical was estimated by using the EPI suite Hydrowin model.

The half life of hydrolysis of test chemical was estimated to be 61.4 and 6.14 days at pH 7 and 8 respectively, the hydrolysis rate constant was estimated to be 1.31 L/mol-sec. On the basis of half life value test chemical is considered to be stable.

Key value for chemical safety assessment

Half-life for hydrolysis:
61.4 d
at the temperature of:
25 °C

Additional information

The half life of test chemical was estimated by using the EPI suite Hydrowin model.

The half life of hydrolysis of test chemical was estimated to be 61.4 and 6.14 days at pH 7 and 8 respectively, the hydrolysis rate constant was estimated to be 1.31 L/mol-sec. On the basis of half life value test chemical is considered to be stable.