Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 303-773-5 | CAS number: 94213-67-9
Fish 96 h-LC50: 0.73 mg/L
In the Klimisch 1 GLP study from Kimmel (2013) the acute toxicity of Sulfosuccinic (FA C16-18/18:1)E, Na/NH4 to zebra fish (Danio rerio) was determined in a 96‑hour semi-static test with daily test medium renewal according to the EU Commission Directive 92/69/, Part C.1, the Commission Regulation (EC) No 440/2008, Part C.1 and the OECD Guideline for Testing of Chemicals No. 203 (1992).
The nominal test item concentrations tested were 0.050, 0.16, 0.50, 1.6 and 5.0 mg/L. Additionally, a control group was tested in parallel. The concentrations of 0.050 and 0.16 mg/L were below the NOEC and hence not analysed. In the analyzed test medium samples from the start of the test medium renewal periods the measured test item concentrations ranged between 97 and 110% of the nominal values. This shows the correct dosage of the test item. During the test medium renewal periods of 24 hours a decrease of the test item concentration in the test media was determined. At the end of the first test medium renewal period, 70 to 83% of the nominal values were found. At the end of the last test medium renewal period, the measured concentration was below LOQ (limit of quantification, LOQ=0.301 mg test item/L). Therefore the biological results were related to the mean measured test item concentrations, i.e., control, 0.36, 1.5 and 4.1 mg/L for the control and nominal 0.50, 1.6 and 5.0 mg/L, respectively.
In the control and at the test concentrations up to and including the mean measured concentration of 0.36 mg/L, all fish survived until the end of the test and no visible abnormalities were observed in the test fish. At the next higher mean measured concentration of 1.5 mg/L, all test fish were dead after 48 hours of test duration. At the highest mean measured concentration of 4.1 mg/L, all fish were dead already after 24 hours of test duration.
The 96‑hour LC50 of Sulfosuccinic (FA C16-18/18:1)E, Na/NH4 was calculated to be 0.73 mg/L with a 95% confidence interval of 0.36 -1.5 mg/L. The 96‑hour LC100 was 1.5 mg/L.
The results of this study are considered relevant and reliable for the risk assessment.
Read across is made from CAS 147993-66 -6 (source) to the substance related to CAS 94213-67-9 (target). Both substances have a similar C-chain distribution. Assessment factors are not needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again