Registration Dossier
Registration Dossier
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EC number: 946-046-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There was no specific data found on toxicokinetics, metabolism and distribution on the reaction mass of 4-sulphophthalic acid and 3-sulphophthalic acid or sulphophthalic acid ammonium or sodium salts. However, from phthalic acid related structural surrogates (e.g. phthalic anhydrides) we can assume that phthalic acid most likely will be excreted in the urine when exposed to sulphophthalic acids (Pfuffli, 1986). The molecular weight of the sulphophthalic acid is considered small enough for absorption (crossing membranes through aqueous pores), together with its hydrophilic nature (negative log P value), and pKa values suggest absorption via the stomach and excretion thru the urine (Lehman-McKeenan, 2008; Eke, 2016).
References:
Eke, BC (2016). Toxicokinetics; Disposition of Xenobiotics (Absorption, Distribution and Excretion of Xenobiotics). Eurotox Basic Toxicology Course. Available at: http://htd.hr/wp-content/uploads/sites/414/2016/04/Lecture_TOXICOKINETICS_Benay-Can-Eke.pdf [Accessed May 12, 2017].
Lehman-McKeeman L. Absorption, Distribution, and Excretion of Toxicants. Chapter 5. In 7th Edition Casarett & Doull’s Toxicology: The Basic Science of Poisons. 2008: 131-159.
Pfäffli P. Phthalic acid excretion as an indicator of exposure to phthalic anhydride in the work atmosphere. Int Arch Occup Environ Health. 1986;58(3):209-16. Available at: http://link.springer.com/article/10.1007/BF00432103 [Accessed May 12 2007]
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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