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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-03-27 to 2017-04-07
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
340 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
500 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 10.8 - <= 11
Details on results:
The results found after an incubation time of 72 hours did not differ by more than 15 % from the result found after an incubation time of 48 hours. The acceptance criteria was fulfilled. Thus, the study is valid.
The test item showed to be stable during the performance of the test.

Table 1. Data of the Performance of the Water Solubility Test

Sample No.

72h-1

72h-2

48h-1

48h-2

24h-1

24h-2

Weighed amount of test

item [mg]

9901.50

10000.23

9890.82

10157.16

10250.97

9959.20

Added volume of water

[mL]

20

20

20

20

20

20

Loading Rate [g/L]

495

500

495

508

513

498

Agitation time at 30 °C

[hours]

72

72

48

48

24

24

Equilibration time at

20 °C [hours]

24

24

24

24

24

24

pH value of test item

solution

10.8

10.9

10.8

10.8

11.0

11.0

 

Table 2. Results of the Water Solubility

Sample No.

Shaking

time at

30 °C

[hours]

Measured

concentration

[mg/L]

Dilution

Factor

Determined

Concentration

[g/L]

Water

Solubility

Mean

Value

[g/L]

Overall

Mean

± Std.

Dev.

[g/L]

72-1

72

66.4

5000

332

337

340

±2

72-2

72

68.5

5000

343

48-1

48

67.6

5000

338

342

48-2

48

69.3

5000

346

24-1

24

68.1

5000

340

340

24-1

24

67.8

5000

339

The tabulated values of the samples represent rounded results obtained by calculation using the exact data.

Conclusions:
The water solubility of the test item was determined at 20 °C using the shake flask method. The water solubility was found to be 340 ± 2 g/L.
Executive summary:

In this study the water solubility of the test item was determined using the shake flask method according to OECD 105. Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection.

The water solubility of the test item was found to be 340 ± 2 g/L.

Description of key information

The water solubility of the test item was found to be 340 ± 2 g/L.

Key value for chemical safety assessment

Water solubility:
340 g/L
at the temperature of:
20 °C

Additional information

In this study the water solubility of the test item was determined using the shake flask method according to OECD 105. Vessels containing water and the test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards, the samples were equilibrated for another 24 hours at 20 °C. Then, the samples were centrifuged and diluted, and the concentrations were determined by HPLC with UV-detection.

The water solubility of the test item was found to be 340 ± 2 g/L.