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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-10-10 to 2016-10-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
17.6 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
6.5
Remarks on result:
other: Overall mean water solubility of measurements of 24, 48 and 72h

The details of the results are presented here:

Stirring time at 30°C [h] Replicate Weighed amount of test item [mg] pH value of test item solution Measured concentration [mg/L] Water solubility Mean value [mg/L] Overall Mean ± Std. Dev. [mg/L]

± Rel. Std. Dev.

[%]

72 1 15.61 6.4 16.7 16.75 17.6 ± 0.8 ± 5
2 16.47 6.42 16.8
3 16.64 6.42 12.1 (a)
48 1 21.01 6.8 20.2 17.7
2 18.16 6.4 17.2
3 17.81 6.41 15.7
24 1 15.62 6.5 17.1 18.3
2 16.16 6.61 19.7
3 17.89 6.55 18.2

The details of the calibration data are presented here:

Concentration of

Test Item

[mg/L]

Sum of Peak Areas

 

[counts]

Deviation of Calculated from Effective Value

[%]

1.63

17517

7.8

3.46

39601

9.4

6.91

69074

-6.1

17.2

184405

-0.9

34.3

373338

0.4

The R² fit of the calibration curve used was 0.9995. This reflects the linearity of the analytical system within the calibration range of 1.63 – 34.3 mg test item /L.

The relative standard deviation was found to be 5 %. Thus, the acceptance criterion was fulfilled and the saturation was achieved after 24 hours.

Conclusions:
The water solubility of the test item was determined at 20 °C at a mean pH value of 6.5 using the shake flask method according to OECD 105.
The water solubility was found to be 17.6 mg/L ± 0.8 mg/L.

Description of key information

The water solubility of the test item was determined according to OECD 105, using the shake flask method. The test item showed a chromatographic profile consisting of several peaks. Two peaks were identified as the main components representing 93 % of the substance. The water solubility, based on the sum of the two main components, was measured to be 17.6 mg/L ± 0.8 mg/L at 20°C at a mean pH value of 6.5.

Key value for chemical safety assessment

Water solubility:
17.6 mg/L
at the temperature of:
20 °C

Additional information