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EC number: 943-728-2 | CAS number: -
The test substance were indicated a 100% sensitisation rate and was classified as a strongly sensitiser to guinea pig skin and the individual skin reactions in test and control animals at challenge were presented in Tables 1 and 2.
In a dermal sensitization study (012/251), with Ligustral/Cyclal C/Trigustral (in 25% and 50% v/v ethanol/diethylphthalate (DEP) 1:1), 38 female albino Dunkin Hartley guinea pigs were tested in the in vivo guinea pig maximisation test.
Based on sighting study results, Ligustral/Cyclal C/Trigustral was used at 5% in arachis oil (intradermal induction), 25% in DEP 1:1 (topical induction) and 50% and 25% in DEP 1:1 for challenge. There was no positive control study conducted concurrently but historical laboratory data indicated that known positive sensitisers produced appropriate sensitisation results using the test system.
The results indicated that Ligustral/Cyclal C/Trigustral was a skin sensitiser at both challenge concentrations in 20/20 animals and no reactions were noted in control groups.
Ligustral/Cyclal C/Trigustral is a dermal sensitizer in this OECD 406 (GPMT) study.
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