Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 277-225-8 | CAS number: 73018-51-6 The complex combination of hydrocarbons obtained by the acid isomerization of linalool. It consists primarily of monoterpenes, terpene alcohols and oxygenated cyclic compounds.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The read-across is based on the hypothesis that the source substance (Sinpine P) and target substance (Lime oxide) have similar ecotoxicological properties as a result of their similar composition, the same expected aquatic toxicity mode of action for the components and similar concentrations of the component blocks (monoterpene hydrocarbons and monoterpene ethers). The component blocks present in both substances also have similar physical chemical properties relevant for exposure to and uptake by aquatic organisms. The expected similar strength in aquatic toxicity is confirmed by experimental data for acute toxicity to daphnia. Full details for the analogue approach justification are provided in the attached document " Acute fish Read-Across Justification for Lime Oxide".
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- 6.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Estimate based on read-across
- Conclusions:
- In a guideline study, conducted according to GLP, the source substance was found to have a 96h LL50 of 6.8mg/L. The detailed information provided in the read-across justification document indicates that the aquatic
ecotoxicity of Sinpine P (source substance) and Lime oxide (target substance) are expected to be similar as a result of similar compositions, the same expected aquatic toxicity mode of action for the components and similar concentrations of each component block (group of structurally similar substances). The component blocks present in both substances also have similar physical chemical properties relevant for exposure to and uptake by aquatic organisms. The read-across is justified and considered adequate for the purposes of classification and labelling.
A reliable estimate of the short-term toxicity to fish for Lime Oxide is a 96h LL50 of 6.8 mg/L.
Reference
Description of key information
The 96h LL50 for Lime Oxide was estimated to be 6.8mg/L based on read-across. This value can be used directly for classification but is unsuitable for derivation of PNEC since partitioning in the environment of the two groups of components present in Lime oxide will make comparison with PEC meaningless. In order to derive appropriate PNECs, acute daphnia information for the two assessment entities has been used since the daphnia endpoint was identified as the most sensitive species for both groups (see aquatic toxicity endpoint summary for details).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6.8 mg/L
Additional information
To assess the acute fish toxicity of the registered substance, read-across to Sinpine P has been employed. The read-across works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. This is an analogue approach for which the read-across hypothesis is based on different substances which have similar properties. The source substance (Sinpine P) and target substance (Lime oxide) are expected to have similar ecotoxicological properties as a result of their similar composition. Many components are common to both substances and others are structurally related. In summary, both substances are mixtures of unsaturated monoterpene hydrocarbons and oxygen-containing monoterpenes. All components are expected to act via narcosis.This mechanism is non-structure dependent and is driven by hydrophobicity (as modelled by log Kow). Thus the components are not expected to influence each other's toxicity and the aquatic toxicity of both multi-constituent substances will be driven by the relative ratio of the unsaturated monoterpene hydrocarbons (estimated log Kow 4.35-4.88) and oxygen-containing monoterpenes (estimated log Kow 2.85-3.53) and the resulting composition of the water-accommodated fractions tested. The relative concentration of the two component blocks is similar in Sinpine P and Lime Oxide (approx 69-74% unsaturated monoterpene hydrocarbons and 23-25% oxygen-containing monoterpenes). The expected similarity in the strength of aquatic toxicity is supported by experimental data for acute toxicity to daphnia (5.3mg/L for the target substance, 2.8 mg/L for the source substance). Therefore, read-across from Sinpine P is considered to give a reliable estimate of the fish 96h LL50 for Lime Oxide, which is 6.8 mg/L based on loading rates. The value is considered adequate for the regulatory purpose of acute enviromental classification. A detailed scientific justification for the read-across is provided as an attachment in the IUCLID endpoint record. The data matrix supporting the read-across is provided below:
Data Matrix – Physicochemical and ecotoxicological data on the source and target substance
Substance Name |
Sinpine P (source substance) |
Lime Oxide (target substance) |
Component Data |
|
|
Monoterpene unsaturated hydrocarbons - Typical total, % w/w - Log Kow (estimated values) - Water solubility, mg/L |
74 4.27 - 4.88 2.22 -7.56 |
69 4.75 – 4.88 2.01 - 9.02 |
Oxygen-containing monoterpenes - Typical total % w/w - Log Kow (estimated values) - Water solubility (estimated values) |
23 2.85 – 3.33 32.28 – 584.1 |
25 3.13-3.54 68.88-584.1 |
Ecotoxicological information |
|
|
Short-term Daphnia toxicity, 48h EL50(mg/L) |
2.8i |
5.3ii |
Growth inhibition study aquatic plant (algae), 72h ErL50(mg/L) |
No data available |
15iii |
Growth inhibition study aquatic plant (algae), 72h ErL10(mg/L) |
No data available |
11iii |
Short-term toxicity to fish, 96h LL50(mg/L) |
6.8iv |
Read-across from source substance |
i) WIL Research, Project 506046, 2015 – presented in the respective REACH dossier of Sinpine P ii) Envigo Research Limited, Study No 41400820, 2015 – included in this REACH dossier iii) Envigo Research Limited, Study No 41400821, 2015- included in this REACH dossier iv) WIL Research, Project 506047, 2015 – included in this REACH dossier |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.