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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute dermal toxicity in rats for CAS no: 57-11-4
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplusA TOXNET Database, 2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of Caprolactam was performed in rats.
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): Caprolactam
- Molecular formula : C6H11NO
- Molecular weight : 113.1589 g/mol
- Smiles notation : C1(CCCCCN1)=O
- InChl : 1S/C6H11NO/c8-6-4-2-1-3-5-7-6/h1-5H2,(H,7,8)
- Substance type: Organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Caprolactam
- Molecular formula : C6H11NO
- Molecular weight : 113.1589 g/mol
- Smiles notation : C1(CCCCCN1)=O
- InChl : 1S/C6H11NO/c8-6-4-2-1-3-5-7-6/h1-5H2,(H,7,8)
- Substance type: Organic
- Physical state: solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2000mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No morality was observed
Mortality:
No morality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be > 2000mg/kg body weight. When rats were treated with Caprolactam (105-60-2) by dermal application.

Executive summary:

Acute dermal toxicity study was done in rats using test material Caprolactam (105-60-2).No mortality was observed at dose 2000mg/kg bw. Hence LD50 was considered to be >2000mg/kg body weight. When rats were treated with Caprolactam (105-60-2) by dermal application.