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Biodegradation in water:

Biodegradability of test chemical 5-acetamido-2-aminobenzenesulphonic acid (CAS no. 96-78-6) is predicted using OECD QSAR tool box v.3.4 using log Kow as primary descriptor. Percent biodegradation of test chemical 5-acetamido-2-aminobenzenesulphonic acid estimated was 10.5 % by considering BOD as parameter and microorganisms as inoculum in 28 days. Therefore it is concluded that test chemical 5-acetamido-2-aminobenzenesulphonic acid is not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96 -78 -6). If released in to the environment, 35 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 5-acetamido-2-aminobenzenesulphonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 5-acetamido-2-aminobenzenesulphonic acid in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0835 %), indicates that test chemical 5-acetamido-2-aminobenzenesulphonic acid is not persistent in sediment.

Biodegradation in soil:

The half-life period of5-acetamido-2-aminobenzenesulphonic acid(CAS No: 96 -78 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 64.9 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical5-acetamido-2-aminobenzenesulphonic acidin soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical5-acetamido-2-aminobenzenesulphonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water:

Predicted data for the target compound 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96-78-6) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below.

Biodegradability of test chemical 5-acetamido-2-aminobenzenesulphonic acid (CAS no. 96-78-6) is predicted using OECD QSAR tool box v.3.4 using log Kow as primary descriptor. Percent biodegradation of test chemical 5-acetamido-2-aminobenzenesulphonic acid estimated was 10.5 % by considering BOD as parameter and microorganisms as inoculum in 28 days. Therefore it is concluded that test chemical 5-acetamido-2-aminobenzenesulphonic acid is not readily biodegradable.

 

Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to predict the biodegradation potential of the test chemical 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96 -78 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 5-acetamido-2-aminobenzenesulphonic acid is not readily biodegradable.

 

In a supporting weight of evidence study for read across chemical 3-Aminobenzene sulphonic acid (CAS no. 121-47-1) from authoritative database (J Check, 2017) biodegradation test was conducted by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using three parameters that are O2 consumption (BOD), TOC removal and test material analysis by UV vis. The initial concentration of read across chemical was 100 mg/L and equipment used in the study used was of standard type. After 4 weeks read across chemical showed 1.1 % degradation by O2 Consumption (BOD) parameter and less than 0.0 % degradation by both TOC removal and Test material analysis by UV vis parameter so it is concluded that read across chemical 3-Aminobenzene sulphonic acid is not readily biodegradable.

 

In another supporting weight of evidence study for read across chemical 2-amino-5-methylbenzene sulfonic acid (CAS no. 88-44-8) from same source as mentioned above (J Check, 2017) biodegradation experiment was performed by taking activated sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using three parameters that are O2 consumption (BOD), TOC removal and test material analysis by UV vis. The initial concentration of read across chemical was 100 mg/L and equipment used in the study was of standard type. After 2 weeks read across chemical showed 0.0 % degradation by O2 Consumption (BOD) parame ter and less than 0.0 % degradation by both TOC removal and Test material analysis by UV vis parameter so it is concluded that read across chemical 2-amino-5-methylbenzene sulfonic acid is not readily biodegradable.

 

On the basis of above results for target chemical 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96-78-6) (from OECD QSAR tool box v3.4 and EPI suite, 2017) and for its read across substance (from authoritative database), it is concluded that the test substance 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96-78-6) can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96 -78 -6). If released in to the environment, 35 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 5-acetamido-2-aminobenzenesulphonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 5-acetamido-2-aminobenzenesulphonic acid in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0835 %), indicates that test chemical 5-acetamido-2-aminobenzenesulphonic acid is not persistent in sediment.

Biodegradation in soil:

The half-life period of5-acetamido-2-aminobenzenesulphonic acid (CAS No: 96 -78 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 64.9 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 5-acetamido-2-aminobenzenesulphonic acidin soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 5-acetamido-2-aminobenzenesulphonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.