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EC number: 210-283-4
CAS number: 611-92-7
test substance, Centralit, was tested for acute dermal toxicity using
was performed according to the Method B.3 Acute Toxicity (Dermal),
Council Regulation (EC) No.440/2008, published in O.J. L 142, 2008.
study was performed as limit test: two groups of animals – 5 males and 5
females at the dose of 2000 mg/kg of body weight. The pre-test was
performed with 1 male and 1 female from each group. After end exposure
test substance of these pilot animals, the other animals of the group
test substance was applied on the shaved skin of the test animals in
delivered form for 24 hours.
test animals were observed 14 days after exposure test substance,
afterwards they were sacrificed, and the necropsy for macroscopic
examination of the organs was performed.
test substance applied at the dose of 2000 mg/kg of body weight did not
cause death of animals. No clinical signs of intoxication were observed.
No macroscopic change was diagnosed during pathological examination of
to the results of study, the value of LD50 (dermal) of the test
substance, Centralit, for rats of both sexes is higher than 2000 mg/kg
of body weight.
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