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Diss Factsheets
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EC number: 946-058-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- EC Number:
- 242-640-5
- EC Name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- Cas Number:
- 18871-14-2
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-O-acetyl-1,5-anhydro-2,4-dideoxy-2-pentylpentitol
- Reference substance name:
- 3-butyltetrahydro-5-methyl-2H-pyran-4-yl acetate
- EC Number:
- 253-863-2
- EC Name:
- 3-butyltetrahydro-5-methyl-2H-pyran-4-yl acetate
- Cas Number:
- 38285-49-3
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-O-acetyl-1,5-anhydro-2-butyl-2,4-dideoxy-4-methylpentitol
- Reference substance name:
- 3-pentyltetrahydro-2H-pyran-4-ol
- Cas Number:
- 24646-98-8
- Molecular formula:
- C10H20O2=
- IUPAC Name:
- 3-pentyltetrahydro-2H-pyran-4-ol
- Reference substance name:
- Likely acetylated constituents, MW 214
- Molecular formula:
- n/a
- IUPAC Name:
- Likely acetylated constituents, MW 214
- Reference substance name:
- Likely acetylated constituents
- Molecular formula:
- n/a
- IUPAC Name:
- Likely acetylated constituents
- Reference substance name:
- Unknown constituent, MW 172
- Molecular formula:
- n/a
- IUPAC Name:
- Unknown constituent, MW 172
- Test material form:
- liquid
- Details on test material:
- UVCB substance
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
impurity 4
- Specific details on test material used for the study:
- Batch no.: PE00138468
Expiry date : 20 February 2018
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Age : 6-7 weeks old
Weight range at arrival : 168.3-189.3 grams
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 300 mg/kg
2000 mg/kg - No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality and no clinical signs were observed in animals of the first group initially dosed at 300mg/kg (Group 12, Step 1). No mortality occurred and no clinical signs were seen in the further group of 3 females dosed at the same dose level (Group 21, Step 2) and in the two groups of 3 females each dosed at 2000mg/kg (Group 24, Step 3; Group 27, Step 4).
- Clinical signs:
- No mortality and no clinical signs were observed in animals of the first group initially dosed at 300mg/kg (Group 12, Step 1). No mortality occurred and no clinical signs were seen in the further group of 3 females dosed at the same dose level (Group 21, Step 2) and in the two groups of 3 females each dosed at 2000mg/kg (Group 24, Step 3; Group 27, Step 4).
- Body weight:
- Changes in body weight observed during the study were within the expected range for this strain and age of animals.
- Gross pathology:
- No abnormalities were observed at necropsy examination performed on all animals dosed at 300 and 2000mg/kg (Groups 12, 21, 24 and 27) at the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The acute toxicity of JASMONYL LG was investigated following a single oral administration at the doses of 300 and 2000mg/kg (10mL/kg in 0.5% aqueous solution of carboxymethylcellulose) to the Sprague Dawley rat followed by a 14-day observation period.
No mortality occurred and no signs of toxicity were observed in the 6 animals following dosing at 2000mg/kg.
These results indicate that the test item JASMONYL LG did not induce toxic effects in the rat following oral administration of a single dose at a level of 2000mg/kg. The lack of mortality demonstrates the acute toxicity expected (ATE) to be greater than 2000mg/kg body weight.
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