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EC number: 700-845-1 | CAS number: 133978-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (no GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Comparable to guideline study with acceptable restrictions (no GLP)
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl 2-cyanoacrylate
- EC Number:
- 230-391-5
- EC Name:
- Ethyl 2-cyanoacrylate
- Cas Number:
- 7085-85-0
- Molecular formula:
- C6H7NO2
- IUPAC Name:
- ethyl 2-cyanoacrylate
- Reference substance name:
- [TN]ethyl 2-cyanoacrylate[/TN][SPEC][/SPEC][AM][/AM]
- IUPAC Name:
- [TN]ethyl 2-cyanoacrylate[/TN][SPEC][/SPEC][AM][/AM]
- Details on test material:
- - Name of test material: Depend, IS 04E, Trade name: Product 495
- 97% ethyl-2 cyanoacyrlate
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- 1-Methylheptyl cyanoacrylate is a structural analogue to 2-ethyl cyanoacrylate. Both substances share the reactive cyanoacrylate function. The chain length of the alcohol moiety in 1-methylheptyl cyanoacrylate is increased compared to 2-ethyl cyanoacrylate. The mentioned cyanoacrylates are very reactive monomers and polymerize immediately (within 30-60 sec) in the presence of moisture based on the same reaction mechanism. The polymerized materials have a high molecular mass and are not able to penetrate through skin or intestinal wall resulting in low bioavailability.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: the body weight ranged from 206 to 246 g
- Fasting period before study: 18 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 6 male albino rats
- Control animals:
- no
- Details on study design:
- The test compound was administered by oral intubation to 1 group of 6 male albino rats fasted for 18 hours prior to dosing. The animals were observed during the day of dosing and daily thereafter for 14 days. All animals were sacrified and necropsied 14 days p.a.. Decents during the study were examined for gross lession.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One rat died on the fourth day.
- Gross pathology:
- The pathological examination showed hemorrhagic lungs, a solid mass in stomach, not adhered to stomach wall but too large to pass through pyloric valve. Cardiac portion of stomach distended. Food in intestines as in a normal rat. One rat had dilated intestinal blood vessels.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of ethyl-2-cyanoacrylate is estimated to be higher than 5000 mg/kg body weight in rats for a single dose.
- Executive summary:
It was the aim of the study with 2-ethylcyanoacrylate to investigate acute toxic effects of the test substance after a single oral administration. Due to structural similarities and a comparable reaction mechanism with water resulting in a polymer, read-across of the result of this study to 1 -methylheptyl cyanoacrylate is justified.
1-Methylheptyl cyanoacrylate will polymerize quickly in contact with water resulting in low bioavailability. Based on the fact that the structural analogue 2-ethyl cyanoacrylate has shown a LD50 of > 5000 mg/kg body weight in an experimental investigation (oral, rat) and the reaction mechanism is the same for 1-methylheptyl cyanoacrylate, it is concluded that 1-methylheptyl cyanoacrylate will also not be of acute oral toxicity and is thus not classified.
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