2-Propenoic acid, 2-cyano-, 1-methylheptyl ester

Endpoint summary

Description of key information

REACH_LD50 > 5000 mg/kg bw  | rat (male/female) | OECD 401 | [TN]ethyl-2cyanoacrylate[/TN][SPEC][/SPEC][AM]97%[/AM]#key study##Analogy#

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Value:

mg/kg bw

Additional information

1-Methylheptyl cyanoacrylate is a structural analogue to 2-ethyl cyanoacrylate. Both substances share the reactive cyanoacrylate function. The chain length of the alcohol moiety in 1-methylheptyl cyanoacrylate is increased compared to 2-ethyl cyanoacrylate. The mentioned cyanoacrylates are very reactive monomers and polymerize immediately (within 30-60 sec) in the presence of moisture based on the same reaction mechanism. The polymerized materials have a high molecular mass and are not able to penetrate through skin or intestinal wall resulting in low bioavailability. Based on this physico-chemical behaviour, conducting an experimental test for assessing the acute oral toxicity of the monomer is technically not meaningful. Thus, it is concluded that for 1-methylheptyl cyanoacrylate data on acute oral toxicity can be drawn from the structural analogue 2-ethyl cyanoacrylate.

It was the aim of the study with 2-ethylcyanoacrylate to investigate acute toxic effects of the test substance after a single oral administration.

 

Methods

The method was similar to the OECD-Guideline 401, "Acute Oral Toxicity".

Administration

Ethyl-2-cyanoacrylate was administered once oral by stomach intubation to 6 male albino rats (5000 mg/kg).

Investigations

The animals were observed during the day of dosing and daily thereafter for 14 days. Necropsy: all animals were sacrificed and necropsied 14 days p.a.

Results

Mortality

One mortality was observed.

Necropsy findings

The pathological examination showed hemorrhagic lungs, a solid mass in stomach, not adhered to stomach wall but too large to pass through pyloric valve. Cardiac portion of stomach distended. Food in intestines as in a normal rat. One rat had dilated intestinal blood vessels.

The LD50 of ethyl-2-cyanoacrylate is estimated to be higher than 5000 mg/kg body weight in rats for a single dose.

Justification for classification or non-classification

1-Methylheptyl cyanoacrylate will polymerize quickly in contact with water resulting in low bioavailability. Based on the fact that the structural analogue 2-ethyl cyanoacrylate has shown an LD50 of > 5000 mg/kg body weight in an experimental investigation (oral, rat) and the reaction mechanism is the same for 1-methylheptyl cyanoacrylate, it is concluded that 1-methylheptyl cyanoacrylate will also not be of acute oral toxicity and is thus not classified.