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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

REACH_LD50 > 5000 mg/kg bw  | rat (male/female) | OECD 401 | [TN]ethyl-2cyanoacrylate[/TN][SPEC][/SPEC][AM]97%[/AM]#key study##Analogy#

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
5 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
mg/kg bw

Additional information

1-Methylheptyl cyanoacrylate is a structural analogue to 2-ethyl cyanoacrylate. Both substances share the reactive cyanoacrylate function. The chain length of the alcohol moiety in 1-methylheptyl cyanoacrylate is increased compared to 2-ethyl cyanoacrylate. The mentioned cyanoacrylates are very reactive monomers and polymerize immediately (within 30-60 sec) in the presence of moisture based on the same reaction mechanism. The polymerized materials have a high molecular mass and are not able to penetrate through skin or intestinal wall resulting in low bioavailability. Based on this physico-chemical behaviour, conducting an experimental test for assessing the acute oral toxicity of the monomer is technically not meaningful. Thus, it is concluded that for 1-methylheptyl cyanoacrylate data on acute oral toxicity can be drawn from the structural analogue 2-ethyl cyanoacrylate.

It was the aim of the study with 2-ethylcyanoacrylate to investigate acute toxic effects of the test substance after a single oral administration.



The method was similar to the OECD-Guideline 401, "Acute Oral Toxicity".


Ethyl-2-cyanoacrylate was administered once oral by stomach intubation to 6 male albino rats (5000 mg/kg).


The animals were observed during the day of dosing and daily thereafter for 14 days. Necropsy: all animals were sacrificed and necropsied 14 days p.a.



One mortality was observed.

Necropsy findings

The pathological examination showed hemorrhagic lungs, a solid mass in stomach, not adhered to stomach wall but too large to pass through pyloric valve. Cardiac portion of stomach distended. Food in intestines as in a normal rat. One rat had dilated intestinal blood vessels.

The LD50 of ethyl-2-cyanoacrylate is estimated to be higher than 5000 mg/kg body weight in rats for a single dose.

Justification for classification or non-classification

1-Methylheptyl cyanoacrylate will polymerize quickly in contact with water resulting in low bioavailability. Based on the fact that the structural analogue 2-ethyl cyanoacrylate has shown an LD50 of > 5000 mg/kg body weight in an experimental investigation (oral, rat) and the reaction mechanism is the same for 1-methylheptyl cyanoacrylate, it is concluded that 1-methylheptyl cyanoacrylate will also not be of acute oral toxicity and is thus not classified.