Registration Dossier
Registration Dossier
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EC number: 500-209-1 | CAS number: 68412-54-4 1 - 2.5 moles ethoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Environmental and human safety of major surfactants, alcohol ethoxylates and alkylphenol ethoxylates
- Author:
- Talmage SS
- Year:
- 1 994
- Bibliographic source:
- Lewis publishers, CRC Press, Inc., 2000 Corporate Bld., N.W., Boca Raton, Florida 33431. ISBN 1-56670-017-5
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- NPE-4
- IUPAC Name:
- NPE-4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No data
Applicant's summary and conclusion
- Conclusions:
- According to the test results, the dermal LC50 for NPE-4 was determined to be greater than 2,000 mg/kg bw.
- Executive summary:
A study was conducted to evaluate the acute dermal toxicity of a commercial formulation of NPE-4 to rabbit. Under the study conditions, the dermal LD50 was > 2,000 mg/kg bw (Talmage SS, 1994).
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