Registration Dossier
Registration Dossier
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EC number: 259-370-9 | CAS number: 54839-24-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Model is based on accepted principles of skin permeation and diffusion of chemicals through a semi-permeable membrane. It was validated with an extensive database of experimentally measured permeation coefficients and is considered valid for substances with log Kow values in the range from 0 to 4.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- Skinperm version 3.0
- Author:
- ten Berge W
- Year:
- 2 015
- Bibliographic source:
- http://home.planet.nl/~wtberge/
Materials and methods
Test material
- Reference substance name:
- 2-ethoxy-1-methylethyl acetate
- EC Number:
- 259-370-9
- EC Name:
- 2-ethoxy-1-methylethyl acetate
- Cas Number:
- 54839-24-6
- Molecular formula:
- C7H14O3
- IUPAC Name:
- 2-ethoxy-1-methylethyl acetate
- Reference substance name:
- 259-770-9
- IUPAC Name:
- 259-770-9
Constituent 1
Constituent 2
Test animals
- Species:
- human
Results and discussion
Percutaneous absorption
- Remarks on result:
- other:
Any other information on results incl. tables
The model estimates the permeation rate for ethoxypropyl acetate liquid to be 0.0497 mg/cm2/hr. For comparison purposes, the model estimates the permeation rate for methoxypropyl acetate to be 0.0505mg/cm3/hr and for the parent glycol ethers ethoxypropanol and methoxypropanol to be 0.223 and 0.169mg/cm2/hr respectively. This indicates that the parent ethers can absorb significantly more rapidly than the esters, by a factor of 3 -4 and that the length of the alkyl chain, at least methyl compared to ethyl has little effect on skin absorption.
Applicant's summary and conclusion
- Executive summary:
A QSAR model predicts that the permeation rate of ethoxypropyl acetate will be 0.050mg/cm2/hr based on the physicochemical properties of the substance. The model predicts that the absorption is a factor of 3 -4x lower than that of the parent glycol ether.
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