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EC number: 921-728-3 | CAS number: 64741-66-8
Irritating to the skin.Not irritating to eyes.
The test substance was irritating to the skin according to the criteria of the EU and the GHS.
Based on the study design the test substance, Hydrocarbons, C7-C9, isoalkanes, is not irritating.
The skin irritation potential of the test substance was determined according to OECD 404 (Total Solvants, 2000). The test substance was applied to the intact skin of rabbits for 4 hours under semiocclusive conditions. After removal of the test substance, no edema, but well-defined to moderate erythema were noted in all three animals. Irritating effects were reversible within 9 days. Under the test conditions, the test substance was irritating to the skin.
The eye irritation potential of the hydrocarbons, C7-C9, isoalkanes was determined by instillation of 0.1 mL of the test material into the conjunctival sac of 3 rabbits (ExxonMobil, 2004). Ocular reactions were examined and scored 1, 24, 48, 72 hours after application. At the 1 hour evaluation, conjunctival redness (grade 2) was observed in all animals. Conjunctival redness (grade 0-1) was also noted in all animals at the 72 hour evaluation. All redness was reversible within 7 days. No corneal opacity, iritis or conjunctival chemosis was noted in any of the 3 rabbits. Two further studies, performed according to OECD 404) showed that no ocular irritation in any animal at any time point could be observed for the compounds ISOPAR E and ISOPAR C (both studies from ExxonMobil, 1997). In another study of ExxonMobil (1977) conducted similar to OECD 405, at 1 hour after administration, 4 of 6 animals showed slight erythema which completely subsided by the 4 hour observation. The remaining 2 animals showed slight or moderate erythema, slight edema, and slight discharge. These irritating effects were fully reversible within 72 hours after administration.Under the test conditions, the test substance was not irritating to the eyes.
Based on the available data, hydrocarbons, C7-C9, isoalkanes were considered as skin irritant.
CLP: Skin Irritation Category 2
The available data on the eye irritating potential of hydrocarbons, C7-C9, isoalkanes, are conclusive but not sufficient for classification.
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