Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15/05/2000 - 14/06/2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to international guideline (OECD Guideline 117) under GLP.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Principles of method if other than guideline:
No data
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dihydrolinalool
- Physical state: Liquid
- Storage condition of test material: In refrigerator, protected from light

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.9
Temp.:
23 °C
pH:
7
Details on results:
Using 50/50 (v/v) acetonitrile/Milli-Q water as the mobile phase and a spectrophotometer set to read the absorbance at 210 nm, one test substance peak with 7 minutes retention time was observed in the chromatograms of the 11.0 mg/l Dihydrolinalool test solution which were recorded for 20 minutes. It was assumed that this peak derives from Dihydrolinalool.

The to (the retention time of the unretarded component) was determined to be 1.14 minutes as a mean value of both measurements (i.e. 1.14 and 1.14 minutes). The calculations were performed using not-rounded concentrations.

Any other information on results incl. tables

Results for test substance and reference substances.

Substance

t-r*

k

Log k

Log Pow

Pow

Reference substances

 

 

 

 

 

Benzylalcohol

1.82

0.592

-0.228

1.1

 

Nitrobenzene

3.68

2.22

0.346

1.9

 

Toluene

7.08

5.20

0.716

2.7

 

Bromobenzene

8.08

6.08

0.784

3.0

 

1,4- dichlorobenzene

11.5

9.11

0.959

3.4

 

Biphenyl

15.4

12.5

1.10

4.0

 

Test substance

6.75

4.91

0.691

2.9 (Intrapolated from the regression line : log k=0.454*logpow - 0.605

(r=0.980, n=6))

 

7.2* 102

* Mean value of the retention times of both chromatograms.

** Intrapolated from the regression line : log k=0.454*logpow - 0.605

(r=0.980, n=6)

 

Applicant's summary and conclusion

Conclusions:
The log Pow of Dihydrolinalool is 2.9.
Executive summary:

The log Pow of dihydrolinalool was investigated according to OECD Guideline 117 under GLP. Using HPLC the log Pow was determined to be 2.9 at 23 °C.