Registration Dossier
Registration Dossier
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EC number: 238-936-9 | CAS number: 14866-33-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Study report from NTRL database
Data source
Reference
- Reference Type:
- secondary source
- Title:
- HUMAN REPEATED INSULT PATCH TEST (HRIPT) WITH DOW CORNING Q9-S700 ANTIMICROBIAL AGENT (now known as DOW CORNING 5700 Antimicrobial Agent)
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- NATIONAL TECHNICAL INFORMATION SERVICE ,OT50546181, 09/01/92,
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Determination of skin sensitization in human by using HUMAN REPEATED INSULT PATCH TEST (HRIPT) method.
- GLP compliance:
- not specified
- Type of study:
- other: HUMAN REPEATED INSULT PATCH TEST (HRIPT)
- Justification for non-LLNA method:
- No data available
Test material
- Reference substance name:
- Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
- EC Number:
- 248-595-8
- EC Name:
- Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
- Cas Number:
- 27668-52-6
- Molecular formula:
- C26H58NO3Si.Cl
- IUPAC Name:
- N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]octadecan-1-aminium chloride
- Reference substance name:
- 1-Octadecanaminium, N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]-, chloride
- IUPAC Name:
- 1-Octadecanaminium, N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]-, chloride
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): 1-Octadecanaminium, N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]-, chloride
- Molecular formula : C26H58Cl1N1O3Si1
- Molecular weight : 496.30g/mol
- Smiles notation : c1ccc(cc1)CCOC(=O)c2cccc[Si](OC)(OC)(OC)CCCN(C)(C)(CL)CCCCCCCCCCCCCCCCCCc2O
- InChl: 1S/C26H58NO3Si.ClH/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-24-27(2,3)25-23-26-31(28-4,29-5)30-6;/h7-26H2,1-6H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-Octadecanaminium, N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]-, chloride
- Molecular formula : C26H58Cl1N1O3Si1
- Molecular weight : 496.30g/mol
- Smiles notation : c1ccc(cc1)CCOC(=O)c2cccc[Si](OC)(OC)(OC)CCCN(C)(C)(CL)CCCCCCCCCCCCCCCCCCc2O
- InChl: 1S/C26H58NO3Si.ClH/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-24-27(2,3)25-23-26-31(28-4,29-5)30-6;/h7-26H2,1-6H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Liquid
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 2%
Challenge
- Route:
- other: No data available
- Vehicle:
- water
- Concentration / amount:
- 2%
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2%
- Clinical observations:
- Non sensitizing
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 2%. Clinical observations: Non sensitizing.
Any other information on results incl. tables
The test substance is estimated to be non sensitizing.
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- Based on above experiment Dow Corning 5700 (27668-52-6) was determined to be not sensitizing.
- Executive summary:
Skin sensitization test was performed by using Human repeated insult patch test (HRIPT) using 2% concentration. The test solution was freshly prepared daily. Based on the above observation Dow Corning 5700 (27668-52-6) was determined to be not sensitizing.
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