Registration Dossier
Registration Dossier
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EC number: 238-936-9 | CAS number: 14866-33-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity study in rabbits for CAS no :27668-52-6
- Author:
- HSDB
- Year:
- 2 017
- Bibliographic source:
- TOXNET Toxicology Data Network, 2017
- Reference Type:
- secondary source
- Title:
- Initial submission: letter from dupont chem co to USEPA toxicity studies with dupont 5700 with cover letter
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- National Technical Information Service, OT50546181, 1992-09-01,
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride in rabbits
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
- EC Number:
- 248-595-8
- EC Name:
- Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride
- Cas Number:
- 27668-52-6
- Molecular formula:
- C26H58NO3Si.Cl
- IUPAC Name:
- N,N-dimethyl-N-[3-(trimethoxysilyl)propyl]octadecan-1-aminium chloride
- Reference substance name:
- 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride
- IUPAC Name:
- 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride
- Molecular formula :C26H58NO3Si.Cl
- Molecular weight :496.30 g/mole
- Substance type:Organic
- Physical state:Liquid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride
- Molecular formula :C26H58NO3Si.Cl
- Molecular weight :496.30 g/mole
- Substance type:Organic
- Physical state:Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rabbits at 2000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 2000 mg/kg bw when rabbits were treated with 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride dermally.
- Executive summary:
In a acute dermal toxicity study,rabbits were treated with1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride (27668 -52 -6) in the concentration of 2000 mg/kg bwdermally. No mortality observed in treated rabbits at 2000 mg/kg bw. Therefore,LD50 was considered to be >2000 mg/kg bw when rabbits were treated with1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride dermally.
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