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EC number: 238-936-9 | CAS number: 14866-33-2
Endpoint summary
Administrative data
Description of key information
Bioaccumulation in aquatic /sediments:
Using BCFBAF Program (v3.00) model of EPI suite 2017 the estimated bio concentration factor (BCF) for Tetraoctylammonium Bromide (CAS No.14866-33-2) is 70.79 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical Tetraoctylammonium Bromide is non bioaccumulative in food chain.
Additional information
Bioaccumulation in aquatic /sediments:
Predicted data from two different sources for the target compound Tetraoctylammonium Bromide (CAS No.14866-33-2) and supporting weight of evidence studies for its read across substance were reviewed for the bioaccumulation end point which is summarized as below:
In a prediction done by using BCFBAF Program (v3.00) model of EPI suite (Estimation Program Interface, 2017) the estimated bio concentration factor (BCF) for Tetraoctylammonium Bromide (CAS No.14866-33-2) is 70.79 L/kg wet-wt at 25 deg. c .
Another prediction done by using Bio-concentration Factor (v12.1.0.50374) module of Advanced Chemistry Development/I-lab predictive model, the bio-concentration Factor of the test chemical Tetraoctylammonium Bromide (CAS no.14866-33-2) at range pH 1-14 was estimated to be 1461 dimensionless.
Last prediction done from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance Tetraoctylammonium Bromide (CAS no.14866-33-2) was estimated to be 56.3 dimensionless it is based on the 5 OECD principles.
In a supporting weight of evidence study from authoritative database ( J check, 2017) of read across chemical N,N-dioctyl-1-octanamine(CAS no 1116-76-3) bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of read across chemical N,N-dioctyl-1-octanamine on test organism Cyprinus carpio. The vehicle used was HCO-40 at first Concentration area 0.5 mg/L and second concentration area 0.05 mg/L. Recovery ratio used was test water at 1st concentration area : 91.1 % and at 2nd concentration area : 101 %, Fish : 97.4 %, and Limit of detection of Test water was at 1st concentration area : 0.001 mg/L, 2nd concentration area : 0.0001 mg/L, Fish : 0.01 mg/L. Nominal concentrations used was 1st Concentration area: 0.05 mg/L (w/v), 2nd Concentration area: 0.005 mg/L (w/v) and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 5.1 ppm(w/v). The lipid content of fish was 5.1 %. Thus according to static Fish Test the BCF value for N, N-dioctyl-1-octanamine was observed to be 23-101 L/kg at dose concentration 0.05 mg/L and 25-143 L/kg at dose concentration 0.005 mg/L on test organism Cyprinus carpio during 8 weeks period. These BCF values indicate that the read across substance N,N-dioctyl-1-octanamine is not bioaccumulative in fish and food chain as these values are far less than 2000 criteria.
In another supporting weight of evidence study from authoritative database Hazardous Substance Data Bank (HSDB, 2017) the BCF value of read across chemical dimethyl(dioctadecyl)azanium chloride (CAS no. 107-64-2) estimated was 71 dimensionless by using log Kow of 3.80 and regression derived equation and it is far less than 2000 criteria so it is concluded that read across chemical dimethyl(dioctadecyl)azanium chloride is non bioaccumulative.
On the basis of above results for target chemical Tetraoctylammonium Bromide (CAS no.14866-33-2) (from EPI suite, ACD lab and CompTox Chemistry Dashboard, 2017) and for its read across substances (from authoritative database J check and HSDB 2017), it can be concluded that the BCF value of test substance Tetraoctylammonium Bromide ranges from 56.3 to 1461 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Tetraoctylammonium Bromide is expected to be non-bioaccumulative in the food chain.
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