Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-100-8 | CAS number: 13161-30-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- HSDB for the CAS: 108-99-6
- Author:
- U.S National Library of Medicine
- Year:
- 2 015
- Bibliographic source:
- Hazardous Substances Data Bank (HSDB), U.S National Library of Medicine, last updated 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of 3-methylpyridine in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- sex: male
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 7 or 14 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- SCORING SYSTEM: Eye irritation was characterized by ocular irritation indices (OII).
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Eye irritation assessments showed that irritation was maximal either 1 hr or 1 day after exposure
- Other effects:
- Histological examination of the eyes showed keratitis lesions in corneal epithelial tissue, fibrillary edematous lamallae dissociation, and cellular inflammatory infiltration.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Eye irritation assessments showed that irritation was maximal either 1 hr or 1 day after exposure. Histological examination of the eyes showed keratitis lesions in corneal epithelial tissue, fibrillary edematous lamallae dissociation, and cellular inflammatory infiltration. Over longer periods of time, which included recovery, 3-methylpyridine was considered to be severely irritating and causes irreversible damage to rabbit eyes.
- Executive summary:
The ocular irritation potential of 3-methylpyridine was assessed in rabbits. Undiluted 3-methylpyridine was applied to the eyes of male New Zealand albino rabbits and observed for signs of irritation till 7 or 14 days.Following 7 or 14 days rabbits were killed and histological examinations were performed on the eyes. Eye irritation was characterized by ocular irritation indices (OII).
Eye irritation assessments showed that irritation was maximal either 1 hr or 1 day after exposure. Histological examination of the eyes showed keratitis lesions in corneal epithelial tissue, fibrillary edematous lamallae dissociation, and cellular inflammatory infiltration. Over longer periods of time, which included recovery, 3-methylpyridine was considered to be severely irritating and causes irreversible damage to rabbit eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
