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EC number: 236-100-8 | CAS number: 13161-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- HSDB for the CAS: 108-99-6
- Author:
- U.S National Library of Medicine
- Year:
- 2 015
- Bibliographic source:
- Hazardous Substances Data Bank (HSDB), U.S National Library of Medicine, last updated 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of 3-methylpyridine in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or test system and environmental conditions:
- sex: male
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- single exposure
- Observation period:
- till 7 or 14 days
- Number of animals:
- no data available
- Details on study design:
- SCORING SYSTEM: The skin irritation potential was characterized by cutaneous primary irritation index (PII)
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- other: 7 or 14 days
- Score:
- 6.8
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Severely irritating to rabbit skin
- Other effects:
- Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin. - Executive summary:
The dermal irritation potential of 3-methylpyridine was assessed in rabbits. Undiluted 3-methylpyridine was applied to the skin of male New Zealand albino rabbits and observed for signs of irritation till 7 or 14 days.Following 7 or 14 days rabbits were killed and histological examinations were performed on the test site.The skin irritation potential was characterized by cutaneous primary irritation index (PII).
The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin.
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