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EC number: 203-499-5 | CAS number: 107-52-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: EC50 >100 mg/l (ASRI), read-across from a structurally-related substance.
Key value for chemical safety assessment
Additional information
There are no reliable microorganism toxicity data available for L6, therefore good quality data for the structurally-related substance, decamethyltetrasiloxane, L4, (CAS 141 -62 -8), have been read across. L6 and L4 are structurally-similar substances, both are linear siloxanes.
L4 is a linear siloxane chain with four silicon atoms, connected by three oxygen atoms. All silicon atoms present are fully substituted with methyl groups. L6 is a structurally related linear siloxane, with six silicon atoms and five oxygen atoms.
L6 and L4 are within an analogue group of siloxane substances within which, in general, there is no evidence of significant toxicity to microorganisms.
The table below presents microorganism toxicity data for substances within the analogue group (I-3) of siloxanes (alkyl, vinyl, aryl or hydrogen substituted).
It is therefore considered valid to read-across the results for L4 to fill the data gap for the registered substance.Additional information is given in a supporting report (PFA, 2015i) attached in Section 13.
Table: Microorganism toxicity data for substances within the siloxane analogue group (I-3) of chemicals
CAS | Name | Result: E(I)C50 | Result: NOEC (or EC10/ EC20) | Guideline Number | Duration | Reliability |
540-97-6 | Dodecamethylcyclohexasiloxane | >100 mg/l |
| OECD 209 | 3hr | 1 |
541-05-9 | Hexamethylcyclotrisiloxane | >100 mg/l | >100 mg/l | OECD 209 | 3hr | 1 |
541-02-6 | Decamethylcyclopentasiloxane | >2000 mg/l |
| C11 | 3hr | 1 |
556-67-2 | Octamethylcyclotetrasiloxane | >10 000 mg/l |
| ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge) | 3hr | 4 (WoE) |
556-67-2 | Octamethylcyclotetrasiloxane | little or no toxicity (24 h): 0.1 g/g solution test mat. based on: reduction in number of viable bacteria |
| Toxicity toEscherichia coliandStaphylococcus aureusat 37°C for 24 hours | 24hr | 4 (WoE) |
107-46-0 | Hexamethyldisiloxane | >100 mg/l | ≥100 mg/l | OECD 209 | 3hr | 1 |
141-62-8 | Decamethyltetrasiloxane | >100 mg/l |
| OECD 209 | 3hr | 1 |
352230-22-9 | Siloxanes and Silicones, di-Ph, Ph (trimethylsilyl)oxy | >1000 mg/l | ≥1000 mg/l | OECD 209 | 3hr | 1 |
2627-95-4 | 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | >1000 mg/l | ≥1000 mg/l Nitrification control indicated no heterotrophic inhibition of respiration rate | OECD 209 | 3hr | 1 |
2554-06-5 | 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane | >1000 mg/l | ≥1000 mg/l Nitrification control indicated no heterotrophic inhibition of respiration rate | OECD 209 | 3hr | 1 |
70131-69-0 | Silsesquioxanes, Phenyl | >1000 mg/l | ≥1000 mg/l Nitrification control indicated no heterotrophic inhibition of respiration rate | OECD 209 | 3 h | 1 |
99363-37-8 | dimethyl, methyl(3-aminopropyl) siloxane, trimethylsiloxy-terminated | > water soluble fraction | ≥ water soluble fraction | OECD 209 | 3hr | 1 |
71750-79-3 | dimethyl, (aminoethylaminopropyl)methyl siloxane, trimethylsiloxy-terminated | > water soluble fraction | ≥ water soluble fraction | OECD 209 | 3hr | 1 |
WoE = Weight of evidence
In the study with L4,an activated sludge respiration inhibition 3 hour EC50value of >100 mg/l was reported.
Reference:
Peter Fisk Associates (2015i), Peter Fisk Associates. Siloxane analogue report. PFA.404.005.008.R2
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