Registration Dossier
Registration Dossier
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EC number: 272-729-4 | CAS number: 68910-05-4 A complex residuum from the fractionation of the reaction products of 2-aminoethanol with ammonia to remove piperazine. It may contain such compounds as 2-[(2-aminoethyl)amino]ethanol, (aminoethyl)piperazine, (hydroxyethyl)piperazine.
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: worker survey
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Piperazine-induced occupational asthma
- Author:
- Hagmar L, Bellander T, Bergöö B, Simonsson BG
- Year:
- 1 982
- Bibliographic source:
- J. Occup. Med. 24, 193-197
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- survey
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Survey of workers in a chemical factory.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Piperazine
- EC Number:
- 203-808-3
- EC Name:
- Piperazine
- Cas Number:
- 110-85-0
- Molecular formula:
- C4H10N2
- IUPAC Name:
- piperazine
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 130
- Sex: 129 male, 1 female - Route of administration:
- inhalation
- Details on study design:
- Inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. 38 persons with asthmatic problems, were examined with spirometry, chest roentgenogram and measurement og IgE and IgG antibodies.
69 former employees were identified as probably having had asthma related to occupational setting. 58 of these were interviewed, and their medical records examined.
Results and discussion
- Results of examinations:
- Eleven persons presently employed were asthmatic or had experienced asthma associated with exposure to chemicals. In 13 former employees medical reports supported the diagnosis of occupational asthma associated with chemicals. The criteria for diagnosis was recurrent dyspnoea with wheezing breathing and coughing, in association with exposure to agent. The agent was judged to be piperazine in 29 persons and ethylene diamine in 3 persons.
Applicant's summary and conclusion
- Conclusions:
- In a survey of workers in a chemical factory inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. From 130 subject exposed, 29 persons were judged to have developed occupational asthma due to exposure of piperazine.
- Executive summary:
In a survey of workers in a chemical factory inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. From 130 subject exposed, 29 persons were judged to have developed occupational asthma due to exposure of piperazine.
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