Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 941-788-4 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- TR-599: Technical Report Pathology Tables and Curves - TR-599: Sodium Tungstate Dihydrate - 3-Month with Perinatal Study Tables - Rats
- Author:
- US NTP
- Year:
- 2 019
- Bibliographic source:
- https://tools.niehs.nih.gov/cebs3/views/?action=main.dataReview&bin_id=14351
Materials and methods
- Objective of study:
- absorption
- excretion
- Principles of method if other than guideline:
- During the 90-day drinking water study with Sodium Tungstate Dihydrate, tungsten concentrations were determined in blood and in urine
- GLP compliance:
- not specified
Test material
- Reference substance name:
- disodium dioxotungstenbis(olate) dihydrate
- EC Number:
- 600-275-2
- Cas Number:
- 10213-10-2
- Molecular formula:
- Na2WO4* 2 H2O
- IUPAC Name:
- disodium dioxotungstenbis(olate) dihydrate
- Test material form:
- solid - liquid: aqueous solution
- Details on test material:
- Sodium tungstate dihydrate (STD, Na2WO4·2H2O, CAS #10213-10-2, Lot #12330JO) was obtained through an NTP analytical chemistry contract at Battelle (Columbus, OH). Stability data provided by Battelle indicated that formulations of STD in tap water were stable for at least 42 days at both 5°C and at room temperature.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- unchanged (no vehicle)
Doses / concentrationsopen allclose all
- Dose / conc.:
- 125 mg/L drinking water
- Dose / conc.:
- 250 mg/L drinking water
- Dose / conc.:
- 500 mg/L drinking water
- Dose / conc.:
- 1 000 mg/L drinking water
- Dose / conc.:
- 2 000 mg/L drinking water
- No. of animals per sex per dose / concentration:
- 5
- Control animals:
- yes, concurrent no treatment
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- on study day 78, a dose-dependent increase in tungsten concentration in blood was observed over all dose groups.
- Type:
- excretion
- Results:
- A dose-dependent increase in tungsten urine concentration was observed for all dose groups on study day 78.
Metabolite characterisation studies
- Metabolites identified:
- no
- Remarks:
- The test substance is inorganic.
Applicant's summary and conclusion
- Conclusions:
- If tungsten is applied in a soluble form (Sodium Tungstate Dihydrate), tungsten ions are found in blood and urine.
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