Sodium 4-(4-substitutedanilino)-4-substituedbut-2-enoate

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 Jul - 16 Aug 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

adopted in 2008

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

adopted in 2012

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Department of Health, London, UK

Type of method:

air comparison pycnometer (for solids)

Test material

Test material information

Constituent 1

Specific details on test material used for the study:

Storage conditions: room temperature in the dark

Results and discussion

Density

Key result

Type:

relative density

Density:

ca. 1.47 other: dimensionless

Temp.:

20 °C

Any other information on results incl. tables

Calibration

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table.

Table 2

Determination	P1 [psig]	P2 [psig]	P3 [psig]	P4 [psig]	Reference Cell Volume [cm^3]	Sample Cell Volume [cm^3]
1	17.242	6.527	17.302	8.572	90.754	148.986
2	17.286	6.546	17.171	8.517	90.551	148.566
3	17.183	6.506	17.497	8.673	90.684	148.822

 

Mean reference cell volume: 90.663 cm³

Mean sample cell volume: 148.792 cm³

As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm³ and 149.225 ± 1.0 cm³  for the reference and sample cell volumes respectively) the gas comparison pycnometer was therefore considered acceptable for use.

 

Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table.

 

Table 3

Determination	Test	P1(sample) [psig]	P2(sample) [psig]	Volume [cm^3]	Density [kg/m^3]	Mean Density [kg/m^3]
1	A	17.193	7.022	17.471	1.476E03	1.469E03
	B	17.348	7.090	17.618	1.464E03
	C	17.165	7.014	17.579	1.467E03
2	A	17.275	7.046	17.172	1.486E03	1.470E03
	B	17.261	7.050	17.478	1.460E03
	C	17.267	7.051	17.432	1.464E03

 

Mean density: 1.47E03 kg/m³

Relative density: 1.47

Temperature: 20.0 ± 1.0 °C             

 

Discussion

Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m³ was obtained.

Conclusion

The density of the test item has been determined to be 1.47E03 kg/m³ at 20.0 ± 1.0 °C;

relative density: 1.47.