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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information


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Administrative data

Description of key information

OECD 422; rat; NOAEL (neurotoxicity) = 800 mg/kg (highest dose level tested). Reliability = 1

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
800 mg/kg bw/day
Study duration:

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test according to OECD Guideline 422 was conducted in rats at dose levels of 0, 10, 50, 200, or 800 mg/kg/day. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 800 mg/kg/day of the test substance.

Justification for classification or non-classification