Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Reliable toxicity studies in fish, invertebrates and micro‑organisms are available for the test substance SPE1415 and the analogue substances ATMP and DTPMP and are included in the dossier. A waiver has been applied to the algal toxicity endpoint. The Key Studies are summarised below:
A reliable short-term toxicity study for the test substance SPE1415 with the freshwater crustacean Daphnia magna is available with a 48-hour EC50 of >100 mg/L. This is the lowest acute toxicity value from the aquatic studies for SPE1415, ATMP and DTPMP. This is supported by short-term toxicity studies with the analogue substances ATMP and DTPMP using Daphnia magna and Chironomus tentans, which report 48-hour EC50 values of 297 and 9,910 mg/L, respectively. Short-term studies with fish report LC50 ranging from 150 to 5,377 mg/L; the highest value relates to a seawater fish study.
Due to the complexing properties of SPE1415 with the essential nutrients present in algal test media it is not considered technically possible to conduct an assessment of the toxicity of SPE1415 to aquatic algae and cyanobacteria. Consequently, 100 mg/L is taken as the short-term toxicity endpoint for SPE1415 in aquatic organisms as this is the lowest acute toxicity value for SPE1415 and the analogue substances ATMP and DTPMP.
There are no freshwater long-term toxicity data available for the test substance SPE1415 but there are three reliable freshwater, long-term toxicity studies for fish and invertebrates with the analogue substances ATMP and DTMP. These long-term toxicity data with fish and invertebrates indicated similar sensitivities. Reliable NOEC values for fish with ATMP and DTPMP are 23 and 25.6 mg/L, respectively. A reliable long-term chronic toxicity study for read-across substance ATMP with the freshwater crustacean Daphnia magna was conducted and the 28-day NOEC (based on adult survival and reproduction) was determined to be >=25 mg/L.
Due to the complexing properties of SPE1415 with the subsequent limitiations on essential nutrients present in algal test media it is not considered technically possible to conduct an assessment of the toxicity of SPE1415 to aquatic algae and cyanobacteria. Consequently 23 mg/L is taken as the long-term toxicity endpoint to aquatic organisms as this is the lowest chronic (NOEC) toxicity value for SPE1415 and the analogue substances ATMP and DTPMP.
Additional supporting data on another confidential analogue substance is discussed in Additional Information.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
