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EC number: - | CAS number: -
P-1826 (AMP, 2-amino-2-methyl-l-proano1) was tested for acute dermal toxicity using 12 rabbits. The Rabbits were split into 3 groups of 4. All rabbits had their abdomens shaved free of hair, 2 animals in each group also had their skin abraded using a blunt hypodermic needle. The test material was applied at doses of 1000, 1500 or 2000 mg/kg bw under an occluded dressing for 24 hours. After the exposure period the rabbits were observed for a further 14 days. Following this first test an additional 8 rabbits were used. The abdomen of each rabbit was shaved and then abraded using a blunt hypodermic needle. These rabbits were exposed for 24 hours to 2000 mg/kg bw AMP and then followed for a further 14 days. A t the end of 24 hr exposure, the intact andabraded treated skin sites were severely irritated and black in color. The sites became necrotic within two to three days and remained necrotic for the 1 4 days. The treated sites had severe eschar forrnation by the 14th day, The rabbits in the three treatment groups lost body weight over the two-week observation period. The animals in all the treated groups showed no signs of toxicity or abnormal pharmacological behavior. At necropsy the organs in all rabbits were grossly normal. The treated skin sites in all the rabbits were necrotic. In conclusion, AMP was dermally nontoxic (LD50 > 2000 mg/kg), but was a severe skin irritant.
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