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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1999-12-09 to 1999-12-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butyloctanoic acid
EC Number:
248-570-1
EC Name:
2-butyloctanoic acid
Cas Number:
27610-92-0
Molecular formula:
C12H24O2
IUPAC Name:
2-butyloctanoic acid
Test material form:
liquid
Details on test material:
- Name of test material: 2-butyl octanoic acid
- Molecular formula: C12H24O2
- Molecular weight: 200.32 g/mole
- Smiles notation: O=C(O)C(CCCCCC)CCCC

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ORGANISMS:
- Source: Harlan Nossan S. r. l., Correzzana (MI), Italy
- Age: approx. 5-6 weeks
- Weight at study initiation: 126-150 g
- Controls: none

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: aqueous solution containing 0.5% (w/v) carboxymethylcellulose
Details on oral exposure:
ADMINISTRATION:
- Doses: single doses of 2000 mg/kg bw
- Volume administered: 10 ml/kg
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Post dose observation period: 14 days
EXAMINATIONS: Observation for clinical signs immediately upon dosing, approx. 1, 2, 4 hours after dosing and daily thereafter. Mortality and morbidity check twice daily. Individual body weights were recorded just prior dosing and 7 and 14 days after.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No animal died during the 14 day post-dose observation period.
Clinical signs:
other: Piloerection, hunched posture, salivation, reduced activity, swollen abdomen, difficulty in moving, hairloss on head and red staining on muzzle. Recovery of clinical signs had occurred by day 2 in females and by day 13 in males
Gross pathology:
No abnormalities were found on necropsy of animals performed on tennination of the study.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lack of mortality demonstrates the LD50 to be in excess of 2000 mg/kg body weight.
Executive summary:

The lack of mortality demonstrates the LD50 to be in excess of 2000 mg/kg body weight.