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EC number: 701-388-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Short-term and long-term aquatic toxicity studies are available for Dantocol DHE and no toxicity was observed at the highest concentration tested in all studies. The studies fulfill the data requirements for the aquatic toxicity endpoints and no further testing is required.
Three reliable short-term toxicity studies in fish (Klimisch 1) are available for the test substance. Studies with rainbow trout (Onchorhynchus mykiss) and zebra fish (Danio rerio) reported 96-hour LC50 values of >100 mg/L based on nominal test concentrations of Dantocol DHE (Goodband and Mullee (2007) and Zhao (2007), respectively). A prolonged toxicity study in zebra fish (Danio rerio) was conducted on a semi-static basis over 14 days. The study was run at the single nominal test concentration of 100 mg/L with test substance renewal every 48 hours. The 14-day NOEC (mortality) was 100 mg/L based on nominal test concentrations. The results of all three studies are consistent and demonstrate that the test substance does not cause significant acute toxicity to freshwater fish over a prolonged time period. Additionally, no other signs of toxicity were observed to fish (including observations of toxicity and changes to weight and length) during an extended acute 14 day test.
The short-term toxicity of Dantocol DHE to aquatic invertebrates (Daphnia magna) was estimated according to the internationally accepted test guideline OECD 202 and to GLP. After 48-hours the EC50 was determined to be >100 mg/L (nominal). The long-term toxicity study was conducted using the aquatic invertebrateDaphnia magnaat a range of concentrations up to 100 mg/L (nominal). After 21-days the NOEC was determined to be 100 mg/L (nominal). These studies demonstrate that Dantocol DHE does not cause significant short-term or long-term toxicity to aquatic invertebrates.
There is one reliable (Klimisch 1) long-term toxicity study with aquatic freshwater algae (Desmodesmus subspicatusis) available for the test substance. The study was conducted to OECD 201 test guideline and according to GLP (SafePharm Laboratories, 2007). The 72-hour EC50 and NOEC (growth rate and yield) were determined to be 100 mg/L based on nominal test concentrations. This study result demonstrates that the test substance does not cause significant toxicity to freshwater algae, under the conditions of the test.
Short-term toxicity studies are available for fish, invertebrates and algae and long-term toxicity studies are available for invertebrates and algae and no toxicity was observed at the highest concentration tested in all of the short- and long-term studies. It is anticipated that toxicity would be unlikely to be observed in a long-term fish test based on the absence of toxicity observed in other aquatic toxicity tests. The long-term fish toxicity test is waived and no further testing is proposed.
Additional information
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