Registration Dossier

Administrative data

Endpoint:
toxicity to microorganisms
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this petroleum substance.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data were calculated by a computer model

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
See "Attached background material" in the "Overall remarks, attachments" section below for the detailed composition used in the modelling for this substance

Sampling and analysis

Analytical monitoring:
not required

Test organisms

Test organisms (species):
Tetrahymena pyriformis

Study design

Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
72 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
72 h
Dose descriptor:
other:
Effect conc.:
76.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Duration:
72 h
Dose descriptor:
other: NOEL
Effect conc.:
3.75 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The estimated 72-hr LL50 value for Tetrahymena pyriformis, one of the most sensitive microorganism species, is 76.7 mg/L. The estimated NOEL for the species is 3.75mg/l
Executive summary:

The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated 72-hr LL50 value forTetrahymena pyriformis, one of the most sensitive microorganism species, is 76.7mg/L. The estimated NOEL for the species is 3.75 mg/l