Registration Dossier
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EC number: 701-124-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Falling short of highest standards concerning aspects of protocol or reporting. Acceptable literature publication. Useful: supporting data.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Untersuchungen zur Stabilitat aromatischer Diisocyanat in Dimethylsulphoxid |(DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test
- Author:
- Gahlmann R, Herbold B, Ruckes A & Seel K
- Year:
- 1 993
- Bibliographic source:
- Zbl.Arbeitsmed. 43: 34-38
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Principles of method if other than guideline:
- Pre-dates, but is similar to, those of 84/449/EEC, B12, and OECD Test Guideline 474.
- GLP compliance:
- no
- Type of assay:
- micronucleus assay
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- 4,4'-diphenylmethane diisocyanate in dimethyl sulphoxide,
suspended in corn oil before use.
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 24 hour
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0-200 mg MDI/kg
Basis:
Results and discussion
Test results
- Sex:
- not specified
- Additional information on results:
- An acute toxicity test gave a 7 day LD50 of about 100 mg/kg.
There were no deaths within 24 hr.
It was concluded that the test substance did not cause micronuclei, and therefore did not induce in vivo chromosomal aberration.
The number of erythrocytes with micronuclei differed little between treated groups and the solvent control.
The only statistically significant decrease in polychromatic erythrocytes occurred when the test substance was used at 200 mg/kg. This was taken to suggest inhibited myelopoietic function of the bone marrow.
When compared with distilled water, dimethyl sulphoxide in corn oil gave a statistically insignificant reduction in polychromatic erythrocytes, and increase in erythrocytes with micronuclei.
Applicant's summary and conclusion
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