Registration Dossier
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EC number: 701-124-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Annex IX states that this study need not be conducted if direct or indirect exposure to soil is unlikely (column 2).
MDI is rapidly hydrolysed in aqueous solution. However, MDI is hydrophobic and poorly soluble in water and thus the heterogeneous reaction with water
or soil is less rapid. The major product of such a reaction is insoluble polyurea.
In the production of PMDI the formation of insoluble polyurea would cause abrasion problems and blockage of valves and pipes and therefore releases of PMDI to effluents are expected to be non-existent. Since production is performed in closed systems, releases to soil and sediment are also expected to be negligible. Furthermore, the EUSES program has been used to calculate PEC values based on measured emission data provided by PMDI producers and
processors, including polyurethane producers (EU MDI Risk Assessment Report: methylenediphenyl diisocyanate (MDI)).
Calculated PEC values were 1.4 x 10-6 mg/l for water, 6.9x 10-5 mg/kg for sediment and ranged from 4.2 x 10-5 to 7.2 x 10-4 mg/kg for
soils/grassland. The corresponding PEC/PNEC ratios would be extremely small and less than 1.
Taking into account the scientific and exposure arguments, it appears appropriate to waiver the long-term fish/plant/soil and sediment toxicity studies.
Key value for chemical safety assessment
Additional information
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