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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals and safety assessment reports

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
Author:
GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
Year:
1994
Bibliographic source:
Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
Reference Type:
review article or handbook
Title:
7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the eye irritation potential of 7-Amino-4-hydroxy-2-naphthalenesulfonic acid in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Molecular formula: C10H9NO4S
- Molecular weight: 239.25g/mol
- Smiles: c12c(cc(S(O)(=O)=O)cc1O)cc(N)cc2
- InChl): 1S/C10H9NO4S/c11-7-1-2-9-6(3-7)4-8(5-10(9)12)16(13,14)15/h1-5,12H,11H2,(H,13,14,15)
- Substance type: organic
- Physical state: solid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
2
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
In an eye irritation study, approx. 50mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the eyes of the rabbits.No eye irritation was observed after 7 days.
Hence,7-amino-4-hydroxy-2-naphthalenesulfonic acidcan be considered not irritating to rabbit eyes.
Executive summary:

In an eye irritation study in rabbits, 50 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid (I acid) was instilled into the conjunctival sac of 2 New Zealand white rabbits and observed for signs of irritation. The animals were observed for 7 days. No eye irritation was observed after 7 days.

Hence, 7 -amino-4 -hydroxy-2 -naphthalenesulfonic acid can be considered not irritating to rabbit eyes.