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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity study in rat for CAS no: 120-18-3
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of 2-Naphthalenesulfonic acid was performed in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):2-Naphthalenesulfonic acid
- Molecular formula :C10H8O3S
- Molecular weight :208.2362 g/mole
- Substance type:Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):2-Naphthalenesulfonic acid
- Molecular formula :C10H8O3S
- Molecular weight :208.2362 g/mole
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
4440 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 440 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 4440mg/kg body weight. When rats were treated with 2-Naphthalenesulfonic acid (120-18-3) orally.
Executive summary:

Acute oral toxicity study was done in rat using 2-Naphthalenesulfonic acid (120-18-3). 50% mortality was observed at dose 4440 mg/kg bw. Hence, LD50 was considered to be 4440mg/kg body weight. When rats were treated with 2-Naphthalenesulfonic acid (120-18-3)orally.