Registration Dossier
Registration Dossier
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EC number: 812-243-7 | CAS number: 1189352-83-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Remarks:
- (study performed according to SOP in a laboratory that conforms to GLP but report not audited by the QAU)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-3-iodo-5-(trifluoromethyl)benzene
- EC Number:
- 812-243-7
- Cas Number:
- 1189352-83-7
- Molecular formula:
- C7 H3 Cl F3 I
- IUPAC Name:
- 1-chloro-3-iodo-5-(trifluoromethyl)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Doses:
- 300 and 2000 mg/kg
- No. of animals per sex per dose:
- 3 females/group
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality observed at both doses.
- Clinical signs:
- No information
- Body weight:
- No information
- Gross pathology:
- No information
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- In this study conducted with MR-008-2 (Q6F62), an intermediate product of ML925 synthesis, the maximal dose tested was non-lethal (2000 mg/kg) and LD50 was higher than 2000 mg/kg. Therefore, MR-008-2 (Q6F62) can be classified in Category 5 of the Globally Harmonized Classification System (GHS).
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