1,8-dihydroxy-4-nitro-5-(phenylamino)anthraquinone

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Refer chapter 13 for the detailed read across justification.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

EC No. 440/2008, 30 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Version / remarks:

13 April 2004

Deviations:

no

Duration:

120 h

pH:

4

Temp.:

50 °C

Initial conc. measured:

ca. 0.1 mg/L

Duration:

120 h

pH:

7

Temp.:

50 °C

Initial conc. measured:

ca. 0.1 mg/L

Duration:

120 h

pH:

9

Temp.:

50 °C

Initial conc. measured:

ca. 0.1 mg/L

Transformation products:

no

Remarks on result:

not determinable because of methodological limitations

Remarks on result:

not determinable because of methodological limitations

Validity criteria fulfilled:

not applicable

Conclusions:

The source substance, FAT 92504/C, is likely to not hydrolyse but show a tautomeric relationship between the keto-enol and the amino-imine and thus after an initial loss of the test item a tautomeric equilibration.

Executive summary:

Assessment of hydrolytic stability of the source substance, FAT 92504/C, was carried out using a procedure designed to be compatible with Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test item is likely to not hydrolyse but show a tautomeric relationship between the keto-enol and the amino-imine and thus after an initial loss of the test item a tautomeric equilibration. Due to the mechanism observed the half-life determination was beyond the scope of the method and therefore no hydrolysis rate could be calculated.

Description of key information

Currently, no study assessing the potential of Disperse Blue 077 to undergo hydrolysis is available. Hence, read-across with Disperse Blue 054/077 was performed. Assessment of hydrolytic stability for the source substance, Disperse Blue 054/077, was carried out using a procedure designed to be compatible with Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The test item is likely to not hydrolyse but show a tautomeric relationship between the keto-enol and the amino-imine and thus after an initial loss of the test item a tautomeric equilibration. Due to the mechanism observed the half-life determination was beyond the scope of the method and therefore no hydrolysis rate could be calculated.