6-aminonaphthalene-1,3-disulphonic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from other databases.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

not specified

Principles of method if other than guideline:

Short term toxicity study of test substance 6 amino-1,3 naphthalene –disulfonic acid on fish were determined for the Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulata species

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material:6 amino-1,3 naphthalene –disulfonic acid
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mole
- Smiles notation: c12c(cc(S(O)(=O)=O)cc1S(O)(=O)=O)cc(N)cc2
- InChl: 1S/C10H9NO6S2/c11-7-1-2-9-6(3-7)4-8(18(12,13)14)5-10(9)19(15,16)17/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

not specified

Details on sampling:

No data available

Vehicle:

not specified

Details on test solutions:

No data available

Test organisms (species):

other: Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate.

Details on test organisms:

No data available

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Remarks on exposure duration:

No data available

Post exposure observation period:

No data available

Hardness:

No data available

Test temperature:

No data available

pH:

No data available

Dissolved oxygen:

No data available

Salinity:

No data available

Conductivity:

No data available

Nominal and measured concentrations:

No data available

Details on test conditions:

No data available

Reference substance (positive control):

not specified

Key result

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: non toxic to fishes

Details on results:

No data available

Results with reference substance (positive control):

No data available

Reported statistics and error estimates:

No data available

Validity criteria fulfilled:

not specified

Conclusions:

Based on the experimental data the lethal concentration (LC0) of test substance substance 6 amino-1, 3 naphthalene –disulfonic acid for fish Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulata was 1000 mg/l for 96 hrs.

Executive summary:

Toxic effects of test substance6 amino-1,3 naphthalene –disulfonic acid was determined on various fish species likeLeuciscus idus, Bruchydunio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate for 96 hrs in static condition and in fresh water.

 

During experiment the lethal concentration (LC0) value was1000 mg/l.

 

Thus based on the above experimental result the test substance6 amino-1,3 naphthalene –disulfonic acid was nontoxic to fishes and thus not consider for the further classification as per the CLP criteria.

Description of key information

Toxic effects of test substance 6 amino-1,3 naphthalene –disulfonic acid was determined on various fish species like Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate for 96 hrs in static condition and in fresh water. During experiment the lethal concentration (LC0) value was1000 mg/l. Thus based on the above experimental result the test substance6 amino-1,3 naphthalene –disulfonic acid was nontoxic to fishes and thus not consider for the further classification as per the CLP criteria

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

1 000 mg/L

Additional information

Based on the various experimental data for the target chemical 6 amino-1,3 naphthalene –disulfonic acid (118-33-2) been reviewed to determine the toxic nature of target chemical 6 amino-1,3 naphthalene –disulfonic acid. The studies are as mentioned below:

In the key study study for the chemical from chemosphere ,Toxic effects of test substance 6 amino-1,3 naphthalene –disulfonic acid was determined on various fish species like Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate for 96 hrs in static condition and in fresh water. During experiment the lethal concentration (LC0) value was1000 mg/l. Thus based on the above experimental result the test substance6 amino-1,3 naphthalene –disulfonic acid was nontoxic to fishes and thus not consider for the further classification as per the CLP criteria.

 

Similarly in the another supporting study for 6 amino-1,3 naphthalene –disulfonic acid from IUCLID dataset 2000. Toxic effects of test substance6 amino-1, 3 naphthalene –disulfonic acid was determined on Leuciscus idus for 96 hrs in static condition and in fresh water. During experiment the lethal concentration (LC0) value was ≥1000 mg/l. Thus based on the above experimental result the test substance6 amino-1, 3 naphthalene –disulfonic acid was nontoxic for fishes and thus not consider for the further classification as per the CLP criteria.

 

Based on the various experimental data for the target chemical 6 amino-1,3 naphthalene –disulfonic acid (118-33-2) from chemosphere and IUCLID dataset, the chemical was not toxic for fishes and thus not consider for the further classification as per the CLP criteria.