4'-sulphamoylacetanilide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary Source

Data source

Reference

Reference Type:

secondary source

Title:

Letter from Eastman kodak Company To USEPA Submitting Enclosed Mater AL Safety Data Sheet and Toxicity Reports on N-Acetylsulfanilyl Chloride with Attachments

Author:

Environmental Protection Agency

Year:

1991

Bibliographic source:

National Technical Reports Library (NTRL), OTS0533563, 1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity study of 4-(acetylamino)-benzenesulfonyl chloride in rat

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-(acetylamino)-benzenesulfonyl chloride

Cas Number:

121-60-8

Molecular formula:

C8H8ClNO3S

IUPAC Name:

4-(acetylamino)-benzenesulfonyl chloride

Details on test material:

- Name of test material (as cited in study report): 4-(acetylamino)-benzenesulfonyl chloride
- Molecular formula (if other than submission substance): C8H8ClNO3S
- Molecular weight (if other than submission substance): 233.6742 g/mole
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report): 4-(acetylamino)-benzenesulfonyl chloride
- Molecular formula (if other than submission substance): C8H8ClNO3S
- Molecular weight (if other than submission substance): 233.6742 g/mole
- Substance type: Organic

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 200 – 3200 mg/kg bw
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: Corn oil
- Lot/batch no. (if required): No data available
- Purity: No data available

MAXIMUM DOSE VOLUME APPLIED: No data available

DOSAGE PREPARATION (if unusual): 4-(acetylamino)-benzenesulfonyl chloride was administrated as a 10 % suspension in corn oil

Doses:

200 – 3200 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Mortality and clinical signs were examined.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 3 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No 50% mortality observed

Mortality:

No 50% mortality observed in treated rat at 3200 mg/kg bw

Clinical signs:

other: Weakness and ataxia were observed in treated rats.

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was considered to be 3200 mg/kg bw when 5 rat were treated with 4-(acetylamino)-benzenesulfonyl chloride orally.

Executive summary:

In a acute oral toxicity study,5 rat were treated with 4-(acetylamino)-benzenesulfonyl chloride in the concentration of 200 – 3200 mg/kg bw orally as a 10 % suspension in corn oil. No 50% mortality observed in treated rat at 3200 mg/kg bw and Weakness and ataxia was observed in treated rats. Therefore,LD50 was considered to be 3200 mg/kg bw when 5 rat were treated with4-(acetylamino)-benzenesulfonyl chloride orally.