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EC number: 205-771-9 | CAS number: 150-78-7
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
In a primary eye irritation study (RCC study number B16086), 0.1 g of Paradimethoxybenzene was instilled into the conjunctival sac of left eye of New Zealand White rabbits (1 male and 2 females). Animals then were observed for 72 hours.
Irritation was scored according to the EU classification criteria.
The mean score was calculated across 3 scoring times (24, 48 and 72 hours after instillation) for each animal for corneal opacity, iris, redness and chemosis of the conjunctivae, separately.
The individual mean scores for corneal opacity and iris were 0.00 for all three animals. The individual mean scores for the conjunctivae were 0.33, 0.33 and 0.67 for reddening, respectively and 0.00 for chemosis for the three animals.
No abnormal findings were observed in the cornea or iris of any animal at any of the measurement intervals In this study, Paradimethoxybenzene is not an eye irritant based on the EU classification criteria.
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