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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No enough details. Documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
Author:
Hodge HC, Sterner JH, Maynard EA, Thomas J.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 79-92.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other:

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS:
- Species: rat
- Strain: no data
- Sex: no data
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: Average weight of animals:
- group tested at 1000 mg: 175 g
- group tested at 1250 mg: 172 g
- group tested at 1500 mg: 176 g
- group tested at 1750 mg: 130 g.
- Fasting period before study: no data
- Housing: no data
- Food consumption: no data
- Water consumption: no data
- Acclimation period: no data

Environmental conditions: no data

In-life dates: no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
- Maximum dose volume applied: 1750 mg
- Dosage preparation (if unusual): no data
- Rationale for the selection of the starting dose: no data
Doses:
1000; 1250; 1500; 1750 mg corresponding to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg.
No. of animals per sex per dose:
for doses of 1000, 1250 and 1500 mg, 10 animals per dose.
For dose of 1750 mg, only one animal.
Sex unspecified.
Control animals:
no
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- examinations performed: other: no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
Mortality:
2/10 died at dose of 1000 mg (5714 mg/kg), whereas, 5/10 died at dose of 1500 mg (8522 mg/kg). One rat treated at dose of 1750 mg/kg, died.
Clinical signs:
no data
Body weight:
The average bodyweight in most of the rats ranged around 175 g.
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

The doses were not indicated in mg/kg bw but only in mg. The LD50 was calculated in accordance with weight of animals.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to EU and UN GHS criterias, the substance is not classified for acute oral toxicity.
Executive summary:

In a oral acute study, rats were exposed to 5714 mg/kg, 7267 mg/kg, 8522  mg/kg and 13461 mg/kg of the test substance. The LD50 is 8500 mg/kg. Based on this value, the substance is not classified for acute oral toxicity.