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Hydrolysis:

The hydrolysis half life at different pH and rate constant of test chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate (CAS No. 102-22-7) was estimated by EPI  Suite (HydroWin). The Half life estimated at pH 7 was 138.033 days and at pH 8 was 13.803 days at temperature 25 oC. The rate Constant at pH > 8 was 0.5812 L/Mol/Sec  at 25 oC. Since, half life of hydrolysis of chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate is more than 10 days it shows negligible hydrolysis in water.

Additional information

Hydrolysis:

Predicted data for target compound (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate (CAS No. 102-22-7) and supporting weight of evidence studies for its read across chemicals were reviewed for the Hydrolysis endpoint which is summarized below.

In a prediction done to estimate the hydrolysis half life at different pH and rate constant of test chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate (CAS No. 102-22-7) by EPI Suite (Estimation Program Interface, 2017) HydroWin Program v.2.00. Estimated Half life at pH 7 was 138.033 days and at pH 8 was 13.803 days at temperature 25 oC. The rate Constant at pH > 8 was 0.5812 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate is more than 10 days it shows negligible hydrolysis in water.

In a supporting weight of evidence study from authoritative database Hazardous Substance Data Bank (HSDB, 2017) of read across chemical eth(5-benzylfuran-3-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate (CAS no.10453-86-8) hydrolysis rate constant obtained was 0.17 L/mol/sec by structure estimation method and second order reaction. The half life of hydrolysis obtained at pH 7 was 1.3 years and at pH 8 was 47 days. Since half life of hydrolysis at both pH is more than 10 days so it is concluded that read across chemical eth(5-benzylfuran-3-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate shows negligible hydrolysis.

In another supporting weight of evidence study from same source as mentioned above (HSDB, 2017) of read across chemical of read across chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate the hydrolysis rate constant obtained was 0.35 L/mol/sec by base catalysed second order reaction and structure estimation method. The half life of hydrolysis obtained at pH 7 was 231 days and at pH 8 was 23 days. Since half life of hydrolysis at both pHs is more than 10 days so it is concluded that test chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate shows negligible hydrolysis.

On the basis of results for target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate (CAS No.102-22-7) (From EPI Suite ) and for its read across chemicals (from HSDB, 2017) it is concluded that target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-phenylacetate is expected to show negligible hydrolysis.