Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Weight of evidence approach
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
The weight of Evidence is justified in the attached Justification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2014

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD 432, OECD 129, ECVAM 139
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Almond, sweet, ext.
EC Number:
291-063-5
EC Name:
Almond, sweet, ext.
Cas Number:
90320-37-9
IUPAC Name:
Proteins from sweet almond extract
Test material form:
liquid
Details on test material:
Amber liquid

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 5 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the weight of evidence approach, the applicant concludes that the substance Proteins from Sweet almond extract do not show acute oral systemic toxicity potentially up to 5000 mg/kg bw. Therefore, no classification for acute oral toxicity is needed.
Executive summary:

Based on these different information, the applicant concludes that the substance Proteins from Sweet almond extract do not show acute oral systemic toxicity potentially up to 5000 mg/kg bw. Therefore, no classification for acute oral toxicity is needed.