Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-07-11 to 2018-10-22
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
GLP compliance:
no
Type of method:
capillary method

Test material

Constituent 1
Chemical structure
Reference substance name:
(2Z)-2-fluoro-3-(morpholin-4-yl)acrylaldehyde
EC Number:
813-789-9
Cas Number:
152873-67-1
Molecular formula:
C7H10FNO2
IUPAC Name:
(2Z)-2-fluoro-3-(morpholin-4-yl)acrylaldehyde
Test material form:
solid
Specific details on test material used for the study:
Name: (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA)
Lot Number: BXR82PT
CAS No.: 152873-67-1
Sponsor No. 2950024288
Aggregate State at Room Temperature: Solid
Colour: Brown
Expiry Date: November 01, 2018
Storage Conditions at Test Facility: At 20 °C ± 5 °C, in the dark

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
>= 101.3 - <= 108.4 °C
Atm. press.:
ca. 1 013 hPa

Applicant's summary and conclusion

Conclusions:
In conclusion (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) melted in the range of 101.3 °C to 108.4 °C (374.4 K to 381.6 K).
Executive summary:

Title:

(2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA): Determination of the Melting Point / Melting Range

Purpose:

The purpose of this study was to evaluate the melting point or melting range of (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) by the capillary method using an electronic controlled heating system.

Guidelines/Recommendations:

This study was based on the procedures indicated by the following internationally accepted methods:

-Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No 440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex V, Part A, A.1.: “Melting /Freezing Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008

-Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.: 102, “Melting Point/Melting Range”, adopted July 27, 1995

-Product Properties Test Guideline of the United States Environment Protection Agency (EPA), OPPTS 830.7200 Melting Point / Melting Range, March 1998

Results:           

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 97 °C. The test item showed all five stages of melting. The melting started at 101.3 °C (stage A). At 108.4 °C the last stage E of melting could be visual observed. At the end of the test the test item was liquid and red.

Conclusion:

In conclusion, the test item (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) melted in the range of 101.3 °C to 108.4 °C (374.4 K to 381.6 K). This study is classified acceptable and satisfies the guideline requirements for melting point studies.