Registration Dossier
Registration Dossier
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EC number: 292-449-6 | CAS number: 90622-47-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study; non-GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Huntingdon Research Centre
- Year:
- 1 984
- Bibliographic source:
- Report No.: 84458D/PEQ/4/SE
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetradecane
- EC Number:
- 211-096-0
- EC Name:
- Tetradecane
- Cas Number:
- 629-59-4
- Molecular formula:
- C14H30
- IUPAC Name:
- tetradecane
- Details on test material:
- 1-Tetradecane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 0
- Remarks on result:
- other: only mild conjunctival reaction were observed.
- Irritant / corrosive response data:
- None of the three animals gave a positive response.
No corneal damage or iridial inflammation was observed.
Temporary mild conjuctival reactions only were seen.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not irritating.
- Executive summary:
The substance is not irritating.
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