p-anisidine

GHS

General Information

Name:

CLP

Implementation:

EU

Remarks:

The substance is listed in Annex VI of CLP as Acute Tox 1, Acute Tox 2, Aquatic Acute 1, STOT RE 2.

This substance is currently listed on the substances list published by ECHA of those whose met REACH Annex III criteria.

The Annex III inventory is an advisory list, there are not detailed information about the used model and the predictions do not follow OECD principles.

Therefore, the following data can only be used as screening information, but they are not to be considered relevant for the classification and labelling :

# Harmonised classification for acute toxicity: The substance is listed in Annex VI of CLP as: Acute Tox. 1; The substance is listed in Annex VI of CLP as: Acute Tox. 2

# Harmonised classification for aquatic toxicity: The substance is listed in Annex VI of CLP as: Aquatic Acute 1

# Harmonised classification for specific target organ toxicity: The substance is listed in Annex VI of CLP as: STOT RE 2

# Suspected carcinogen: The Toolbox profiler Carcinogenicity (genotox and nongenotox) alerts by ISS gives an alert for carcinogenicity; CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (good reliability); ISS Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (good reliability); equivocal carcinogenicity data according to ISSCAN

# Suspected hazardous to the aquatic environment: EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.3304 mg/L (EXPERIMENTAL value); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is Toxic-3 (between 10 and 100 mg/l) (good reliability);The Danish QSAR database contains information indicating that the substance has a 96h LC50 to fish of 67.89 mg/L; The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of <1 mg/L; The Danish QSAR database contains information indicating that the substance has a 96h EC50 to green algae of 2.22 mg/L

# Suspected mutagen: The Toolbox profiler in vitro mutagenicity (Ames test) alerts by ISS gives an alert for mutagenicity; The Toolbox profiler Protein binding alerts for Chromosomal aberration by OASIS v1.1 gives an alert for mutagenicity; CAESAR Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); ISS Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); KNN Mutagenicity model in VEGA (Q)SAR platform predicts that the chemical is Mutagen (EXPERIMENTAL value); The outcome in CTA assay is positive according to ISSCTA; mutagen according to ISSSTY

# Suspected persistent in the environment: The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable

# Suspected skin sensitiser: CAESAR skin sensitisation model in VEGA (Q)SAR platform predicts that the chemical is Sensitizer (good reliability)

Related composition

Related composition:

Boundary composition

legal entity composition

Classification

Physical hazards

Explosives

Reason for no classification:

data lacking

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data lacking

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data lacking

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data lacking

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data lacking

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 2

Hazard statement:

H300: Fatal if swallowed.

Acute toxicity - dermal

Hazard category:

Acute Tox. 1

Hazard statement:

H310: Fatal in contact with skin.

Acute toxicity - inhalation

Hazard category:

Acute Tox. 2

Hazard statement:

H330: Fatal if inhaled.

Skin corrosion / irritation

Reason for no classification:

data lacking

Serious eye damage / eye irritation

Reason for no classification:

data lacking

Respiratory sensitisation

Reason for no classification:

data lacking

Skin sensitisation

Reason for no classification:

data lacking

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data lacking

Carcinogenicity

Reason for no classification:

data lacking

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data lacking

1. Specific target organ toxicity - repeated (STOT-RE)

Hazard category:

STOT Rep. Exp. 2

Hazard statement:

H373: May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Affected organs:

other: high respiratory tract

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data lacking

Hazardous to the ozone layer

Reason for no classification:

data lacking

Labelling

Signal word:

Danger

Hazard pictogram

GHS06: skull and crossbones

GHS08: health hazard

GHS09: environment

Hazard statements

H300: Fatal if swallowed.

H330: Fatal if inhaled.

H310: Fatal in contact with skin.

H373: May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H400: Very toxic to aquatic life.