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EC number: 203-462-3 | CAS number: 107-10-8
Summary of Micronucleus Test Results:
Micronuclei in PCE´s (‰)
Micronuclei in NCE´s (‰)
x: p ≤ 0.01
After the single administration of the highest dose of 800 mg/kg body weight, 1.8 ‰ polychromatic erythrocytes containing micronuclei were found after 24 hours and 1.1 ‰ after 48 hours. In the two lower dose groups rates of micronuclei of about 1.7 ‰ (400 mg/kg group) and 1.2 ‰ (200 mg/kg group) were detected after a sacrifice interval of 24 hours in each case.
With 22.6 ‰ the positive control substance cyclophosphamide for clastogenicity, as expected, led to a clear increase in the number of polychromatic erythrocytes containing exclusively small micronuclei at a dose level of 20 mg/kg body weight. With 91.2 ‰ the positive control vincristine for spindle poison effects also led to a clearly enhanced number of micronuclei containing polychromatic erythrocytes with the expected amount of large micronuclei, i.e. 10.8 ‰.
The number of normochromatic erythrocytes containing micronuclei did not differ to any appreciable extent in the negative control or in the various dose groups at any of the sacrifice intervals. Thus, the test substance Mono-n-butylamin-hydrochlorid 63 % did not lead to any increase in the rate of micronuclei. The number of normochromatic or polychromatic erythrocytes containing small micronuclei (d < D/4) or large micronuclei (d > D/4) did not deviate from the solvent control value at any of the sacrifice intervals.
Thus, under experimental conditions chosen here, Mono-n-butylamin-hydrochlorid 63% does not have any clastogenic effect, and there were no indications of any impairment of chromosome distribution in the course of mitosis.
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