Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
49 CFR 173.240 Method
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Clear colorless liquid
No other data

Test animals

Species:
rabbit
Strain:
other: albino
Details on test animals and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
no
Amount / concentration applied:
No data
Duration of treatment / exposure:
24 hours
Observation period:
3 days
Number of animals:
6
Details on study design:
No data

Results and discussion

In vivo

Irritant / corrosive response data:
When exposures were terminated, all treated sites were thick and erythematous; surface dermatolysis was present in 3 of the animals.
Subsequently, these sites became dry, hard and concave,. This reaction is characteristic of dry necrosis.

Any other information on results incl. tables

When exposures were terminated, all treated sites were thick and erythematous; surface dermatolysis was present in three of the animals. Subsequently these sites became dry, hard, and concave. This reaction is characteristic of dry necrosis.

Under these experimental conditions, mono-n-propylamine is considered as corrosive to the skin.

Applicant's summary and conclusion