Registration Dossier

Administrative data

Description of key information

Irritation:
- skin: corrosive
- eye: corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

In a primary skin irritation study n-propylamine caused surface dermatolysis in three out of six animals. Subsequently these sites became dry, hard, and concave. This reaction is characteristic of dry necrosis (Pennwalt 1977; reliability score: 2). Corrosive to highly irritating effects to skin were found in a second study (Smyth et al. 1962; reliability score: 2).

In a primary eye irritation study corrosive effects (corneal opacity) could be observed (Pennwalt 1977; reliability score 2). A further publication confirmed these results (Smyth et al.1962; reliability score: 2).


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin

Due to the effects seen in two older but valid studies, n-propylamine is considered as corrosive to the skin.

Eye

Due to the reported corneal injury of the rabbit eye in two studies, n-propylamine is considered as corrosive.

EU classification according to Annex VI of Directive 67/548/EEC: C, R34